An intrinsic S/G 2 checkpoint enforced by ATR-Reference-Cited by-同舟云学术

An intrinsic S/G 2 checkpoint enforced by ATR

Published:2018-08-24 Issue:6404 Volume:361 Page:806-810
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Saldivar Joshua C.¹^ORCID,Hamperl Stephan¹,Bocek Michael J.¹,Chung Mingyu¹^ORCID,Bass Thomas E.²^ORCID,Cisneros-Soberanis Fernanda³⁴,Samejima Kumiko³^ORCID,Xie Linfeng⁵^ORCID,Paulson James R.⁵^ORCID,Earnshaw William C.³^ORCID,Cortez David²^ORCID,Meyer Tobias¹^ORCID,Cimprich Karlene A.¹^ORCID

Affiliation:

1. Department of Chemical and Systems Biology, Stanford University School of Medicine, 318 Campus Drive, Stanford, CA 94305-5441, USA.

2. Department of Biochemistry, Vanderbilt University School of Medicine, 2215 Garland Avenue, Nashville, TN 37232, USA.

3. Wellcome Centre for Cell Biology, University of Edinburgh, King’s Buildings, Max Born Crescent, Edinburgh EH9 3BF, Scotland, UK.

4. Unidad de Investigación Biomédica en Cáncer, Instituto de Investigaciones Biomédicas–Universidad Nacional Autónoma de México; Insituto Nacional de Cancerología, México City 14080, Mexico.

5. Department of Chemistry, University of Wisconsin–Oshkosh, 800 Algoma Boulevard, Oshkosh, WI 54901, USA.

Abstract

An additional cell cycle checkpoint Cell division is controlled by checkpoints that regulate the temporal order of the cell cycle phases, including the G 1 /S, G 2 /M, and metaphase/anaphase transitions. Yet there are no known control mechanisms for a fourth fundamental transition—the S/G 2 transition. Saldivar et al. report a switchlike control mechanism that regulates the S/G 2 transition. The checkpoint kinase ATR senses ongoing DNA replication in S phase and represses the mitotic transcriptional network, ensuring that DNA replication in S phase is completed before mitosis. Science , this issue p. 806

Funder

National Institutes of Health

American Cancer Society

Burroughs Wellcome Fund

German Research Foundation DFG

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference22 articles.

1. D. O. Morgan The Cell Cycle: Principles of Control (Primers in Biology New Science Press in association with Oxford Univ. Press 2007).

2. DNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation