PCGF3/5–PRC1 initiates Polycomb recruitment in X chromosome inactivation-Reference-Cited by-同舟云学术

PCGF3/5–PRC1 initiates Polycomb recruitment in X chromosome inactivation

Published:2017-06-09 Issue:6342 Volume:356 Page:1081-1084
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Almeida Mafalda¹^ORCID,Pintacuda Greta¹^ORCID,Masui Osamu²^ORCID,Koseki Yoko²,Gdula Michal¹^ORCID,Cerase Andrea¹^ORCID,Brown David³^ORCID,Mould Arne⁴^ORCID,Innocent Cassandravictoria⁵^ORCID,Nakayama Manabu⁶,Schermelleh Lothar⁵^ORCID,Nesterova Tatyana B.¹^ORCID,Koseki Haruhiko²,Brockdorff Neil¹^ORCID

Affiliation:

1. Developmental Epigenetics, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.

2. Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro, Tsurumi-ku, Yokohama 230-0045, Japan.

3. Chromatin Biology and Transcription, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.

4. Mammalian Development, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.

5. Micron Advanced BioImaging Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.

6. Kazusa DNA Research Institute, 2-6-7 Kazusa-Kamatari, Kisarazu, Chiba, 292-0818, Japan.

Abstract

Polycomb steps to inactivate X XX females silence one of their X chromosomes. This involves a process whereby a noncoding RNA known as Xist coats one of the X chromosomes and recruits chromatin silencing factors. The Polycomb complexes PRC1 and PRC2 are also known to be involved in X chromosome inactivation. Almeida et al. elucidate a key role of a specific complex, PCGF3/5-PRC1, in initiating Polycomb recruitment by Xist RNA. They further demonstrate that Polycomb recruitment is critical for Xist-mediated chromosome silencing and female embryogenesis. Science , this issue p. 1081

Funder

Wellcome Trust

H2020 European Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference33 articles.

1. A new world of Polycombs: unexpected partnerships and emerging functions

2. Polycomb Group Proteins Ring1A/B Link Ubiquitylation of Histone H2A to Heritable Gene Silencing and X Inactivation

3. Establishment of Histone H3 Methylation on the Inactive X Chromosome Requires Transient Recruitment of Eed-Enx1 Polycomb Group Complexes

4. Role of Histone H3 Lysine 27 Methylation in X Inactivation

5. Polycomb Proteins Targeted by a Short Repeat RNA to the Mouse X Chromosome

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