A cargo-sorting DNA robot-Reference-Cited by-同舟云学术

A cargo-sorting DNA robot

Published:2017-09-15 Issue:6356 Volume:357 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Thubagere Anupama J.¹^ORCID,Li Wei¹,Johnson Robert F.¹^ORCID,Chen Zibo¹^ORCID,Doroudi Shayan²^ORCID,Lee Yae Lim³^ORCID,Izatt Gregory²⁴^ORCID,Wittman Sarah²^ORCID,Srinivas Niranjan⁴^ORCID,Woods Damien²^ORCID,Winfree Erik¹²⁴^ORCID,Qian Lulu¹²^ORCID

Affiliation:

1. Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA.

2. Computer Science, California Institute of Technology, Pasadena, CA 91125, USA.

3. Electrical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

4. Computation and Neural Systems, California Institute of Technology, Pasadena, CA 91125, USA.

Abstract

Sorting molecules with DNA robots Single-stranded DNA robots can move over the surface of a DNA origami sheet and sort molecular cargoes. Thubagere et al. developed a simple algorithm for recognizing two types of molecular cargoes and their drop-off destinations on the surface (see the Perspective by Reif). The DNA robot, which has three modular functional domains, repeatedly picks up the two types of molecules and then places them at their target destinations. No additional power is required because the DNA robot does this by random walking across the origami surface. Science , this issue p. eaan6558 ; see also p. 1095

Funder

National Science Foundation

Burroughs Wellcome Fund

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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