Clonal hematopoiesis in human aging and disease-Reference-Cited by-同舟云学术

Clonal hematopoiesis in human aging and disease

Published:2019-11 Issue:6465 Volume:366 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Jaiswal Siddhartha¹^ORCID,Ebert Benjamin L.²³^ORCID

Affiliation:

1. Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

2. Department of Medical Oncology, Howard Hughes Medical Institute, Boston, MA.

3. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Abstract

Cryptic signs of aging in our blood Time is not a friend to our DNA. Aging is associated with an accumulation of somatic mutations in normal dividing cells, including the hematopoietic stem cells (HSCs) that give rise to all blood cells. Certain mutations in HSCs confer a fitness advantage that results in clonal expansions of mutant blood cells that sometimes—but not always—forecast the development of cancer and other age-related diseases. Jaiswal and Ebert review this process of “clonal hematopoiesis,” including the mechanisms by which it arises and the current state of knowledge regarding its effects on human health. Science , this issue p. eaan4673

Funder

National Institutes of Health

Burroughs Wellcome Fund

Edward P. Evans Foundation

Ludwig Institute for Cancer Research

Fondation Leducq

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference98 articles.

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