Large Shifts in Pathogen Virulence Relate to Host Population Structure-Reference-Cited by-同舟云学术

Large Shifts in Pathogen Virulence Relate to Host Population Structure

Published:2004-02-06 Issue:5659 Volume:303 Page:842-844
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Boots M.¹²³,Hudson P. J.¹²³,Sasaki A.¹²³

Affiliation:

1. Department of Animal and Plant Sciences, University of Sheffield, Western Bank, Sheffield S10 2TN, UK.

2. Department of Biology, Mueller Lab, Penn State University, University Park, PA 16802, USA.

3. Laboratory of Mathematical Biology, Kyushu University, Higashi-ku, Fukuoka-shi, Japan.

Abstract

Theory on the evolution of virulence generally predicts selection for an optimal level of virulence determined by trade-offs with transmission and/or recovery. Here we consider the evolution of pathogen virulence in hosts who acquire long-lived immunity and live in a spatially structured population. We show theoretically that large shifts in virulence may occur in pathogen populations as a result of a bistability in evolutionary dynamics caused by the local contact or social population structure of the host. This model provides an explanation for the rapid emergence of the highly virulent strains of rabbit hemorrhagic disease virus.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference12 articles.

1. The New Killer Diseases 2003

2. S. J. Schrag, P. Wiener, Trends Ecol. Evol.10, 319 (1995).

3. Epidemiology and genetics in the coevolution of parasites and hosts

4. R. M. Anderson, R. M. May, Parasitology85, 411 (1982).

5. Invasion, stability and evolution to criticality in spatially extended, artificial host—pathogen ecologies

Cited by 155 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Effect of resistant compartment on pathogen strategy in partially migratory populations;2024-06-17

2. Wildlife–Livestock Host Community Maintains Simultaneous Epidemiologic Cycles of Mycoplasma conjunctivae in a Mountain Ecosystem;Veterinary Sciences;2024-05-14

3. Multispecies interactions and the community context of the evolution of virulence;2024-03-30

4. Resource asynchrony and landscape homogenization as drivers of virulence evolution: The case of a directly transmitted disease in a social host;Ecology and Evolution;2024-02

5. Neotropical bee microbiomes point to a fragmented social core and strong species-level effects;Microbiome;2023-07-14