Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

Author:

Wu Xueling1,Zhou Tongqing1,Zhu Jiang1,Zhang Baoshan1,Georgiev Ivelin1,Wang Charlene1,Chen Xuejun1,Longo Nancy S.1,Louder Mark1,McKee Krisha1,O’Dell Sijy1,Perfetto Stephen1,Schmidt Stephen D.1,Shi Wei1,Wu Lan1,Yang Yongping1,Yang Zhi-Yong1,Yang Zhongjia1,Zhang Zhenhai12,Bonsignori Mattia3,Crump John A.45,Kapiga Saidi H.6,Sam Noel E.56,Haynes Barton F.3,Simek Melissa7,Burton Dennis R.89,Koff Wayne C.7,Doria-Rose Nicole A.10,Connors Mark10,Mullikin James C.11,Nabel Gary J.1,Roederer Mario1,Shapiro Lawrence12,Kwong Peter D.1,Mascola John R.1,

Affiliation:

1. Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.

2. Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.

3. Duke Human Vaccine Institute, Duke University School of Medicine, and Duke University Medical Center, Durham, NC 27710, USA.

4. Division of Infectious Diseases and International Health, Department of Medicine, and Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.

5. Kilimanjaro Christian Medical Centre and Kilimanjaro Christian Medical College, Tumaini University, Moshi, Tanzania.

6. Kilimanjaro Reproductive Health Programme, Moshi, Tanzania.

7. International AIDS Vaccine Initiative (IAVI), New York, NY 10038, USA.

8. Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.

9. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Cambridge, MA 02129, USA.

10. Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

11. NIH Intramural Sequencing Center (NISC), National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Broadly neutralizing antibodies to HIV with similar specificities can be found in multiple HIV-infected individuals.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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