Organic Glasses with Exceptional Thermodynamic and Kinetic Stability

Author:

Swallen Stephen F.123,Kearns Kenneth L.123,Mapes Marie K.123,Kim Yong Seol123,McMahon Robert J.123,Ediger M. D.123,Wu Tian123,Yu Lian123,Satija Sushil123

Affiliation:

1. Department of Chemistry, University of Wisconsin–Madison, Madison, WI 53706, USA.

2. School of Pharmacy, University of Wisconsin–Madison, Madison, WI 53705, USA.

3. Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.

Abstract

Vapor deposition has been used to create glassy materials with extraordinary thermodynamic and kinetic stability and high density. For glasses prepared from indomethacin or 1,3-bis-(1-naphthyl)-5-(2-naphthyl)benzene, stability is optimized when deposition occurs on substrates at a temperature of 50 K below the conventional glass transition temperature. We attribute the substantial improvement in thermodynamic and kinetic properties to enhanced mobility within a few nanometers of the glass surface during deposition. This technique provides an efficient means of producing glassy materials that are low on the energy landscape and could affect technologies such as amorphous pharmaceuticals.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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