Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency-Reference-Cited by-同舟云学术

Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency

Published:2015-04-24 Issue:6233 Volume:348 Page:448-453
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ciancanelli Michael J.¹,Huang Sarah X. L.²³,Luthra Priya⁴,Garner Hannah⁵,Itan Yuval¹,Volpi Stefano⁶⁷,Lafaille Fabien G.¹,Trouillet Céline⁵,Schmolke Mirco⁴,Albrecht Randy A.⁴⁸,Israelsson Elisabeth⁹,Lim Hye Kyung¹,Casadio Melina¹,Hermesh Tamar¹,Lorenzo Lazaro¹⁰¹¹,Leung Lawrence W.⁴,Pedergnana Vincent¹⁰¹¹,Boisson Bertrand¹,Okada Satoshi¹¹²,Picard Capucine¹¹⁰¹¹¹³,Ringuier Benedicte¹⁴,Troussier Françoise¹⁵,Chaussabel Damien⁹¹⁶,Abel Laurent¹¹⁰¹¹,Pellier Isabelle¹⁷¹⁸,Notarangelo Luigi D.⁶,García-Sastre Adolfo⁴⁸¹⁹,Basler Christopher F.⁴,Geissmann Frédéric⁵,Zhang Shen-Ying¹¹⁰¹¹,Snoeck Hans-Willem²³,Casanova Jean-Laurent¹¹⁰¹¹²⁰²¹

Affiliation:

1. St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.

2. Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, USA.

3. Department of Medicine, Columbia University Medical Center, New York, NY, USA.

4. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

5. Centre for Molecular and Cellular Biology of Inflammation (CMCBI), King’s College London, London SE1 1UL, UK.

6. Division of Immunology and Manton Center for Orphan Disease Research, Children’s Hospital, Harvard Medical School, Boston, MA, USA.

7. Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, 16132 Genoa, Italy.

8. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

9. Department of Systems Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA.

10. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France.

11. University Paris Descartes, Imagine Institute, Paris, France.

12. Department of Pediatrics, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan.

13. Study Centre for Primary Immunodeficiencies, AP-HP, Necker Hospital, Paris, France.

14. Pediatric Intensive Care Unit, University Hospital, Angers, France.

15. General Pediatrics Unit, University Hospital, Angers, France.

16. Department of Systems Biology, Sidra Medical and Research Center, Doha, Qatar.

17. Pediatric Immunology, Hematology and Oncology Unit, University Hospital Centre of Angers, Angers, France.

18. INSERM U892, CNRS U6299, Angers, France.

19. Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

20. Pediatric Immuno-Hematology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.

21. Howard Hughes Medical Institute, New York, NY, USA.

Abstract

A genetic cause for severe influenza Although chicken soup and plenty of rest get most kids through an influenza virus infection, some require hospitalization. Ciancanelli et al. report on one child who suffered severely from influenza because of null mutations in the gene for transcription factor IRF7. Cells isolated from this patient could not make enough secreted antiviral proteins, called interferons, to halt viral replication. The requirement for IRF7 seems quite specific, because this patient recovers normally from other common childhood viral infections. Science , this issue p. 448

Funder

NIH

National Center for Research Resources

St. Giles Foundation

National Center for Advancing Translational Sciences

ERC

French National Research Agency

INSERM

Paris Descartes University

Rockefeller University

Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases

Center for Research on Influenza Pathogenesis

Center of Excellence for Influenza Research and Surveillance

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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