Spatial colocalization and functional link of purinosomes with mitochondria-Reference-Cited by-同舟云学术

Spatial colocalization and functional link of purinosomes with mitochondria

Published:2016-02-12 Issue:6274 Volume:351 Page:733-737
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

French Jarrod B.¹,Jones Sara A.²,Deng Huayun³,Pedley Anthony M.⁴,Kim Doory²⁵,Chan Chung Yu⁶,Hu Haibei³,Pugh Raymond J.⁴,Zhao Hong⁴,Zhang Youxin²,Huang Tony Jun⁶,Fang Ye³,Zhuang Xiaowei²⁵⁷,Benkovic Stephen J.⁴

Affiliation:

1. Department of Biochemistry and Cell Biology, Department of Chemistry, Stony Brook University, Stony Brook, NY 11794, USA.

2. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

3. Biochemical Technologies, Science and Technology Division, Corning Incorporated, Corning, NY 14831, USA.

4. Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.

5. Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.

6. Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA.

7. Department of Physics, Harvard University, Cambridge, MA 02138, USA.

Abstract

Spatial control of cellular enzymes Purine is a building block of DNA and also a component of ATP that is used as an energy source in the cell. Enzymes involved in purine biosynthesis organize into dynamic bodies called purinosomes. French et al. found that purinosomes colocalize with mitochondria, organelles that generate ATP (see the Perspective by Ma and Jones). Dysregulation of mitochondria caused an increase in the number of purinosomes. This suggests a synergy, with the purinosomes supplying the purine required for ATP production and in turn using ATP in the biosynthetic pathway. A master regulator of cellular metabolism, mTOR, appears to mediate the association of purinosomes and mitochondria. This could make purine and ATP synthesis responsive to changes in the metabolic needs of the cell. Science , this issue p. 733 ; see also p. 670

Funder

National Institutes of Health

Howard Hughes Medical Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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