Protein Friction Limits Diffusive and Directed Movements of Kinesin Motors on Microtubules-Reference-Cited by-同舟云学术

Protein Friction Limits Diffusive and Directed Movements of Kinesin Motors on Microtubules

Published:2009-08-14 Issue:5942 Volume:325 Page:870-873
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Bormuth Volker¹,Varga Vladimir¹,Howard Jonathon¹,Schäffer Erik²

Affiliation:

1. Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.

2. Nanomechanics Group, Biotechnology Center, TU Dresden, Tatzberg 47-51, 01307 Dresden, Germany.

Abstract

Friction in Microscopic Motor Friction arises because adhesive bonds between two bodies must be broken in order for them to move relative to each other. Now Bormuth et al. (p. 870 ; see the Perspective by

Veigel and Schmidt

) have used single molecule measurements to characterize the frictional drag force of kinesin-8 motor proteins interacting with their microtubule track. Friction, arising from rupture of bonds with the track, constrains the speed and efficiency of the motor protein.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference34 articles.

1. The nonlinear nature of friction

2. Probing the Relation Between Force—Lifetime—and Chemistry in Single Molecular Bonds

3. Single-cell force spectroscopy

4. Origin of Friction Derived from Rupture Dynamics

5. J. Howard Motor Proteins and the Cytoskeleton (Sinauer Associates Sunderland MA 2001).

Cited by 197 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Classical tribology and charge-energy evolution theory cooperate to determine nitrided ceramic coating/metal substrate interfacial friction;Acta Materialia;2024-09

2. Exerting pulling forces in fluids by directional disassembly of microcrystalline fibres;Nature Nanotechnology;2024-07-29

3. Illuminating Pathways to Dynamic Nanotribology: Light‐Mediated Active Control of Interfacial Friction with Nanosuspensions;Small;2024-07-16

4. Microtubule dynamic instability is sensitive to specific biological viscogensin vitro;2024-05-27

5. Statistical Mechanics Approaches for Studying Temperature and Rate Effects in Multistable Systems;Symmetry;2024-05-20