Dynamic Signaling Network for the Specification of Embryonic Pancreas and Liver Progenitors-Reference-Cited by-同舟云学术

Dynamic Signaling Network for the Specification of Embryonic Pancreas and Liver Progenitors

Published:2009-06-26 Issue:5935 Volume:324 Page:1707-1710
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Wandzioch Ewa¹,Zaret Kenneth S.¹

Affiliation:

1. Cell and Developmental Biology Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

Abstract

Integrating Organ Induction During animal development, multiple signaling pathways specify the induction of organ progenitors such as those in the pancreas and liver. Wandzioch and Zaret (p. 1707 ) investigated how three signaling pathways converge on the earliest genes specifying these organs. Within hours, multiple changes were observed in the inductive network with different signals operating in parallel. The findings may help to explain the incomplete programming seen in various stem cell differentiation protocols.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference31 articles.

1. BMP-4 is required for hepatic specification of mouse embryonic stem cell–derived definitive endoderm

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4. The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice

5. A bipotential precursor population for pancreas and liver within the embryonic endoderm

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