Viscous control of cellular respiration by membrane lipid composition-Reference-Cited by-同舟云学术

Viscous control of cellular respiration by membrane lipid composition

Published:2018-12-07 Issue:6419 Volume:362 Page:1186-1189
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Budin Itay¹²^ORCID,de Rond Tristan¹³^ORCID,Chen Yan¹⁴^ORCID,Chan Leanne Jade G.¹,Petzold Christopher J.¹⁴^ORCID,Keasling Jay D.¹²⁵⁶⁷^ORCID

Affiliation:

1. Joint BioEnergy Institute, 5885 Hollis Street, Emeryville, CA 94608, USA.

2. Department of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA 94720, USA.

3. Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.

4. Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

5. Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA.

6. QB3 Institute, University of California, Berkeley, Berkeley, CA 94270, USA.

7. The Novo Nordisk Foundation Center for Sustainability, Technical University of Denmark, Denmark.

Abstract

How membrane viscosity affects respiration In bacteria, energy production by the electron transport chain occurs at cell membranes and can be influenced by the lipid composition of the membrane. Budin et al. used genetic engineering to influence the concentration of unsaturated branched-chain fatty acids and thus control membrane viscosity (see the Perspective by Schon). Experimental measurements and mathematical modeling indicated that rates of respiratory metabolism and rates of cell growth were dependent on membrane viscosity and its effects on diffusion. Experiments on yeast mitochondria also showed similar effects. Maintaining efficient respiration may thus place evolutionary constraints on cellular lipid composition. Science , this issue p. 1186 ; see also p. 1114

Funder

National Science Foundation

U.S. Department of Energy

Adolph C. and Mary Sprague Miller Institute for Basic Research in Science, University of California Berkley

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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