Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells-Reference-Cited by-同舟云学术

Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells

Published:2020-02-07 Issue:6478 Volume:367 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Rigau Marc¹²³^ORCID,Ostrouska Simone⁴⁵^ORCID,Fulford Thomas S.¹,Johnson Darryl N.¹³,Woods Katherine⁴⁵⁶^ORCID,Ruan Zheng¹³,McWilliam Hamish E.G.¹⁷^ORCID,Hudson Christopher⁶^ORCID,Tutuka Candani⁴⁵^ORCID,Wheatley Adam K.¹⁸^ORCID,Kent Stephen J.¹⁸^ORCID,Villadangos Jose A.¹⁷^ORCID,Pal Bhupinder⁴⁵,Kurts Christian²^ORCID,Simmonds Jason⁹^ORCID,Pelzing Matthias⁹,Nash Andrew D.⁹,Hammet Andrew⁹^ORCID,Verhagen Anne M.⁹,Vairo Gino⁹^ORCID,Maraskovsky Eugene⁹^ORCID,Panousis Con⁹,Gherardin Nicholas A.¹^ORCID,Cebon Jonathan⁴⁵⁶¹⁰¹¹^ORCID,Godfrey Dale I.¹³^ORCID,Behren Andreas⁴⁵⁶¹⁰^ORCID,Uldrich Adam P.¹³^ORCID

Affiliation:

1. Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria 3010, Australia.

2. University of Bonn, Bonn, Germany.

3. Australian Research Council Centre of Excellence for Advanced Molecular Imaging at the University of Melbourne, Victoria 3010, Australia.

4. Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria 3084, Australia.

5. School of Cancer Medicine, La Trobe University, Heidelberg, Victoria 3084, Australia.

6. Ludwig Institute for Cancer Research, Melbourne -Austin Branch, Victoria 3084, Australia.

7. Department of Biochemistry and Molecular Biology at the Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia.

8. Australian Research Council Centre of Excellence for Convergent Bio-Nano Science and Technology at the University of Melbourne, Victoria 3010, Australia.

9. CSL Limited at the Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia.

10. Department of Medicine, The University of Melbourne, Melbourne, Victoria 3010, Australia.

11. Austin Health, Heidelberg, Victoria 3084, Australia.

Abstract

A weird way to recognize phosphoantigens In contrast to the well-studied αβ T cells, which recognize peptide antigens presented by major histocompatibility complex (MHC) and MHC-like molecules, how γδ T cells recognize antigens remains largely a mystery. One major class of γδ T cells, designated Vγ9Vδ2 + , is activated by small, phosphorylated nonpeptide antigens, or phosphoantigens, produced by microbes and cancer cells. Rigau et al. found that these cells needed the combination of two immunoglobulin superfamily members, butyrophilin 2A1 (BTN2A1) and BTN3A1, on their cell surface to recognize these phosphoantigens. BTN2A1 directly binds the Vγ9 + domain of the T cell receptor (TCR), whereas a second ligand, potentially BTN3A1, binds the Vδ2 and γ-chain regions on the opposite side of the TCR. A better understanding of this unexpected form of T cell antigen recognition should inform and enhance future γδ T cell–mediated immunotherapies. Science , this issue p. eaay5516

Funder

Australian Research Council

National Health and Medical Research Council

Cancer Council Victoria

Operational Infrastructure Support Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference39 articles.

1. T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules

2. Stimulation of Human γδ T Cells by Nonpeptidic Mycobacterial Ligands