Biased partitioning of the multidrug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity

Author:

Bergmiller Tobias1ORCID,Andersson Anna M. C.1ORCID,Tomasek Kathrin1,Balleza Enrique2ORCID,Kiviet Daniel J.3,Hauschild Robert1ORCID,Tkačik Gašper1ORCID,Guet Călin C.1ORCID

Affiliation:

1. Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria.

2. Faculty of Arts and Sciences, Center for Systems Biology and Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

3. Department of Environmental System Science, ETH Zurich, Swiss Federal Institute of Technology, 8092 Zurich, Switzerland, and Department of Environmental Microbiology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Duebendorf, Switzerland.

Abstract

Drug efflux machinery inherited asymmetrically In dividing bacterial cells, asymmetric distribution of cell wall constituents occurs between mother cells and their progeny. Asymmetric distribution of efflux machinery in a growing population of bacterial cells results in heterogeneity in antibiotic resistance. One consequence is that in the presence of low levels of antibiotic, older cells tend to live longer than younger cells. Using a microfluidic device to trap and measure dividing cells, Bergmiller et al. showed that AcrAB-TolC, the main multidrug efflux pump of Escherichia coli , clusters at the pole of older cells (see the Perspective by Barrett et al. ). As cell division proceeds and daughter cells age, they too gradually accumulate polar efflux pumps. Science , this issue p. 311 ; see also p. 247

Funder

Swiss National Science Foundation

Austrian Science Fund

CONACYT-Mexico

PEW latin american fellows program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3