Affiliation:
1. Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, Box 63, New York, NY 10065 USA.
Abstract
DEET (
N,N
-diethyl-meta-toluamide) is the world's most widely used topical insect repellent, with broad effectiveness against most insects. Its mechanism of action and molecular target remain unknown. Here, we show that DEET blocks electrophysiological responses of olfactory sensory neurons to attractive odors in
Anopheles gambiae
and
Drosophila melanogaster
. DEET inhibits behavioral attraction to food odors in
Drosophila
, and this inhibition requires the highly conserved olfactory co-receptor OR83b. DEET inhibits odor-evoked currents mediated by the insect odorant receptor complex, comprising a ligand-binding subunit and OR83b. We conclude that DEET masks host odor by inhibiting subsets of heteromeric insect odorant receptors that require the OR83b co-receptor. The identification of candidate molecular targets for the action of DEET may aid in the design of safer and more effective insect repellents.
Publisher
American Association for the Advancement of Science (AAAS)
Reference29 articles.
1. J. G. Breman, Am. J. Trop. Med. Hyg.64, 1 (2001).
2. DEET mosquito repellent sold through social marketing provides personal protection against malaria in an area of all-night mosquito biting and partial coverage of insecticide-treated nets: a case-control study of effectiveness
3. ODOR-MEDIATED BEHAVIOR OF AFROTROPICAL MALARIA MOSQUITOES
4. S. J. Moore, A. Lenglet, in Traditional Medicinal Plants and Malaria, M. Wilcox, G. Bodeker, P. Rasoanaivo, Eds. (CRC Press, Taylor and Francis, London, 2004), pp. 343–363.
5. New Mosquito Repellents1
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