Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4-Reference-Cited by-同舟云学术

Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4

Published:1999-02-05 Issue:5403 Volume:283 Page:845-848
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Peled Amnon¹,Petit Isabelle¹,Kollet Orit¹,Magid Michal¹,Ponomaryov Tanya¹,Byk Tamara¹,Nagler Arnon²,Ben-Hur Herzl³,Many Ariel⁴,Shultz Leonard⁵,Lider Ofer¹,Alon Ronen¹,Zipori Dov⁶,Lapidot Tsvee¹

Affiliation:

1. Department of Immunology and

2. Hadassah University Hospital Jerusalem, 91120, Israel.

3. Kaplan Medical Center, Rehovot 76100, Israel.

4. Sourasky Medical Center, Tel Aviv 64239, Israel.

5. The Jackson Laboratory, Bar Harbor, ME 04609, USA.

6. Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.

Abstract

Stem cell homing and repopulation are not well understood. The chemokine stromal cell–derived factor-1 (SDF-1) and its receptor CXCR4 were found to be critical for murine bone marrow engraftment by human severe combined immunodeficient (SCID) repopulating stem cells. Treatment of human cells with antibodies to CXCR4 prevented engraftment. In vitro CXCR4-dependent migration to SDF-1 of CD34 + CD38 −/low cells correlated with in vivo engraftment and stem cell function. Stem cell factor and interleukin-6 induced CXCR4 expression on CD34 + cells, which potentiated migration to SDF-1 and engraftment in primary and secondary transplanted mice. Thus, up-regulation of CXCR4 expression may be useful for improving engraftment of repopulating stem cells in clinical transplantation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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