Unstable Tandem Repeats in Promoters Confer Transcriptional Evolvability-Reference-Cited by-同舟云学术

Unstable Tandem Repeats in Promoters Confer Transcriptional Evolvability

Published:2009-05-29 Issue:5931 Volume:324 Page:1213-1216
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Vinces Marcelo D.¹²³,Legendre Matthieu¹⁴,Caldara Marina¹,Hagihara Masaki⁵,Verstrepen Kevin J.¹²³

Affiliation:

1. FAS Center for Systems Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA.

2. Laboratory for Systems Biology, Flanders Institute for Biotechnology (VIB), Katholieke Universiteit Leuven (K.U. Leuven), B-3001 Heverlee, Belgium.

3. Genetics and Genomics Group, Centre of Microbial and Plant Genetics (CMPG), K.U. Leuven, Gaston Geenslaan 1, B-3001 Leuven (Heverlee), Belgium.

4. Structural and Genomic Information Laboratory, CNRS-UPR 2589, IFR-88, Université de la Méditerranée Parc Scientifique de Luminy, Avenue de Luminy, FR-13288 Marseille, France.

5. The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, 567-0047, Japan.

Abstract

Genotype, Phenotype, and Variation Phenotypic evolution results from changes in coding sequences, as well as in regulatory regions of the genome. Vinces et al. (p. 1213 ) uncover an abundant source of gene expression variability in the promoters of Saccharomyces cerevisiae genes. Up to 25% of yeast promoter regions contain a highly variable tandem repeat sequence, which effect gene expression and local chromatin structure. The intrinsic instability of these repeats generates variability in gene expression levels and provides a mechanism for rapid evolution of phenotypic traits.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference25 articles.

1. Timescales of Genetic and Epigenetic Inheritance

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