Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria-Reference-Cited by-同舟云学术

Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria

Published:2018-02-02 Issue:6375 Volume:359 Page:592-597
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Dejea Christine M.¹²,Fathi Payam¹²³,Craig John M.⁴^ORCID,Boleij Annemarie¹⁵^ORCID,Taddese Rahwa⁵^ORCID,Geis Abby L.¹²^ORCID,Wu Xinqun¹³^ORCID,DeStefano Shields Christina E.¹²^ORCID,Hechenbleikner Elizabeth M.⁶^ORCID,Huso David L.⁷,Anders Robert A.⁸,Giardiello Francis M.²³,Wick Elizabeth C.⁶,Wang Hao¹²,Wu Shaoguang¹³,Pardoll Drew M.¹²,Housseau Franck¹²^ORCID,Sears Cynthia L.¹²³^ORCID

Affiliation:

1. Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA.

2. Department of Oncology, Johns Hopkins University, Baltimore, MD, USA.

3. Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.

4. Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.

5. Department of Pathology, Radboud University Medical Center, Postbus 9101, 6500 HB Nijmegen, Netherlands.

6. Department of Surgery, Johns Hopkins University, Baltimore, MD, USA.

7. Department of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD, USA.

8. Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.

Abstract

Biofilms provide refuge for cancerous bacteria Familial adenomatous polyposis (FAP) causes benign polyps along the colon. If left untreated, FAP leads to a high incidence of colon cancer. To understand how polyps influence tumor formation, Dejea et al. examined the colonic mucosa of FAP patients. They discovered biofilms containing the carcinogenic versions of the bacterial species Escherichia coli and Bacteroides fragilis . Colon tissue from FAP patients exhibited greater expression of two bacterial genes that produce secreted oncotoxins. Studies in mice showed that specific bacteria could work together to induce colon inflammation and tumor formation. Science , this issue p. 592

Funder

National Institutes of Health

National Cancer Institute

Alexander and Margaret Stewart Trust

Bristol Myers Squibb International Immuno-Oncology Network

Netherlands Organization of Scientific Research

Institute Merieux

American Society of Colon and Rectal Surgeons

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary