An Expressed Fgf4 Retrogene Is Associated with Breed-Defining Chondrodysplasia in Domestic Dogs-Reference-Cited by-同舟云学术

An Expressed Fgf4 Retrogene Is Associated with Breed-Defining Chondrodysplasia in Domestic Dogs

Published:2009-08-21 Issue:5943 Volume:325 Page:995-998
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Parker Heidi G.¹,VonHoldt Bridgett M.²,Quignon Pascale¹,Margulies Elliott H.³,Shao Stephanie¹,Mosher Dana S.¹,Spady Tyrone C.¹,Elkahloun Abdel¹,Cargill Michele⁴,Jones Paul G.⁵,Maslen Cheryl L.⁶,Acland Gregory M.⁷⁸,Sutter Nathan B.⁸,Kuroki Keiichi⁹,Bustamante Carlos D.¹⁰,Wayne Robert K.²,Ostrander Elaine A.¹

Affiliation:

1. Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

2. Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA 90095, USA.

3. Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

4. Affymetrix Corporation, 3420 Central Expressway, Santa Clara, CA 95051, USA.

5. The WALTHAM Centre for Pet Nutrition, Waltham on the Wolds, Leicestershire LE14 4RT, UK.

6. Division of Cardiovascular Medicine, Oregon Health and Science University, Portland, OR 97239, USA.

7. Baker Institute for Animal Health, Cornell University, Ithaca, NY 14853, USA.

8. College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.

9. Comparative Orthopaedic Laboratory, University of Missouri, Columbia, MO 65211, USA.

10. Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY, USA.

Abstract

Going Retro In a year celebrating Darwin, the question of how new functional genes arise during evolution is of particular interest. Through a multibreed genetic analysis of the domestic dog, Parker et al. (p. 995 , published online 16 July; see the Perspective by

Kaessmann

) find that the short-legged phenotype that characterizes at least 19 common dog breeds, including the corgi, dachshund, and basset hound, is specifically associated with the expression in developing bone of a gene encoding fibroblast growth factor 4 ( fgf4 ), a member of a gene family previously implicated in dwarfism in humans. Interestingly, the culprit fgf4 gene in dogs has the hallmarks of a “retrogene,” a gene that arises when a parental gene is duplicated through an RNA-based copying mechanism.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference34 articles.

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