Comparative Genome and Proteome Analysis of Anopheles gambiae and Drosophila melanogaster

Author:

Zdobnov Evgeny M.1,von Mering Christian1,Letunic Ivica1,Torrents David1,Suyama Mikita1,Copley Richard R.2,Christophides George K.1,Thomasova Dana1,Holt Robert A.3,Subramanian G. Mani3,Mueller Hans-Michael1,Dimopoulos George4,Law John H.5,Wells Michael A.5,Birney Ewan6,Charlab Rosane3,Halpern Aaron L.3,Kokoza Elena7,Kraft Cheryl L.3,Lai Zhongwu3,Lewis Suzanna8,Louis Christos9,Barillas-Mury Carolina10,Nusskern Deborah3,Rubin Gerald M.8,Salzberg Steven L.11,Sutton Granger G.3,Topalis Pantelis9,Wides Ron12,Wincker Patrick13,Yandell Mark3,Collins Frank H.14,Ribeiro Jose15,Gelbart William M.16,Kafatos Fotis C.1,Bork Peer1

Affiliation:

1. European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

2. Wellcome Trust Center for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.

3. Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA.

4. Department of Biological Sciences, Center for Molecular Microbiology and Infection, Imperial College, London SW7 2AZ, UK.

5. University of Arizona, Tucson, AZ 85721–0088, USA.

6. European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

7. Institute of Cytology and Genetics, Sibirian Division of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.

8. University of California, Berkeley, CA 94720–3200, USA.

9. Institute for Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Post Office Box 1527, GR-711 10 Heraklion, Crete, Greece, and University of Crete, GR-711 10 Heraklion, Crete, Greece.

10. Colorado State University, Fort Collins, CO 80523–1671, USA.

11. The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.

12. Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

13. Genoscope/Centre National de Sequencage and CNRS-UMR 8030, 2 rue Gaston Cremieux, 91057 Evry Cedex 06, France.

14. Center for Tropical Disease Research and Training, University of Notre Dame, Notre Dame, IN 46556–0369, USA.

15. Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, 4 Center Drive, MSC 0425, Bethesda, MD 20892–0425, USA.

16. Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.

Abstract

Comparison of the genomes and proteomes of the two diptera Anopheles gambiae and Drosophila melanogaster , which diverged about 250 million years ago, reveals considerable similarities. However, numerous differences are also observed; some of these must reflect the selection and subsequent adaptation associated with different ecologies and life strategies. Almost half of the genes in both genomes are interpreted as orthologs and show an average sequence identity of about 56%, which is slightly lower than that observed between the orthologs of the pufferfish and human (diverged about 450 million years ago). This indicates that these two insects diverged considerably faster than vertebrates. Aligned sequences reveal that orthologous genes have retained only half of their intron/exon structure, indicating that intron gains or losses have occurred at a rate of about one per gene per 125 million years. Chromosomal arms exhibit significant remnants of homology between the two species, although only 34% of the genes colocalize in small “microsyntenic” clusters, and major interarm transfers as well as intra-arm shuffling of gene order are detected.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3