Affiliation:
1. Program in Molecular Biology, Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
Abstract
Although ubiquitinated histones are present in substantial levels in vertebrate cells, the roles they play in specific biological processes and the cellular factors that regulate this modification are not well characterized. Ubiquitinated H2B (uH2B) has been identified in the yeast
Saccharomyces cerevisiae
, and mutation of the conserved ubiquitination site is shown to confer defects in mitotic cell growth and meiosis. uH2B was not detected in
rad6
mutants, which are defective for the ubiquitin-conjugating enzyme Ubc2, thus identifying Rad6 as the major cellular activity that ubiquitinates H2B in yeast.
Publisher
American Association for the Advancement of Science (AAAS)
Reference53 articles.
1. Workman J., Kingston R., Annu. Rev. Biochem. 67, 545 (1998);
2. Kuo M.-H., Allis D., Bioessays 20, 615 (1998).
3. K. E. van Holde in Chromatin A. Rich Ed. (Springer-Verlag New York 1988) pp. 111–148; A. Wolffe Chromatin Structure and Function (Academic Press San Diego CA ed. 3 1998);
4. Wolffe A., Hayes J., Nucleic Acid Res. 27, 711 (1999).
5. Barsoum J., Varshavsky A., J. Biol. Chem. 260, 7688 (1985);
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