Hox Genes Regulate Digit Patterning by Controlling the Wavelength of a Turing-Type Mechanism-Reference-Cited by-同舟云学术

Hox Genes Regulate Digit Patterning by Controlling the Wavelength of a Turing-Type Mechanism

Published:2012-12-14 Issue:6113 Volume:338 Page:1476-1480
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Sheth Rushikesh¹,Marcon Luciano²³,Bastida M. Félix¹⁴,Junco Marisa¹,Quintana Laura²³,Dahn Randall⁵,Kmita Marie⁶,Sharpe James²³⁷,Ros Maria A.¹⁴

Affiliation:

1. Facultad de Medicina, Instituto de Biomedicina y Biotecnología de Cantabria, Consejo Superior de Investigaciones Científicas–Sociedad para el Desarrollo Regional de Cantabria–Universidad de Cantabria, 39011 Santander, Spain.

2. European Molecular Biology Laboratory (EMBL)–Centre for Genomic Regulation (CRG) Systems Biology Research Unit, CRG, Doctor. Aiguader 88, 08003 Barcelona, Spain.

3. Universitat Pompeu Fabra, 08003 Barcelona, Spain.

4. Departamento de Anatomía y Biología Celular, Universidad de Cantabria, 39011 Santander, Spain.

5. 7322 Countrywood Lane, Madison, WI 53719, USA.

6. Institut de Recherches Cliniques de Montréal, Université de Montréal, Montréal, Québec H2W 1R7, Canada.

7. Institució Catalana de Recerca i Estudis Avançats, Passeig Lluís Companys 23, 08010 Barcelona, Spain.

Abstract

Digit Determination Pentadactyly has been an early and rapid innovation of tetrapods. Sheth et al. (p. 1476 ) report that a dramatic reduction in distally expressed Hox genes, in the absence of a functional morphogen signaling pathway, results in extreme polydactyly in mice. Mutant digits exhibited patterns reminiscent of the endoskeleton of fins, suggesting that an ancestral patterning mechanism has been deeply conserved in evolution.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference46 articles.

1. How do we get a perfect complement of digits?

2. Vertebrate limb bud development: moving towards integrative analysis of organogenesis

3. Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb

4. Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity

5. Progression of Vertebrate Limb Development Through SHH-Mediated Counteraction of GLI3

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