Developmental Decline in Neuronal Regeneration by the Progressive Change of Two Intrinsic Timers-Reference-Cited by-同舟云学术

Developmental Decline in Neuronal Regeneration by the Progressive Change of Two Intrinsic Timers

Published:2013-04-19 Issue:6130 Volume:340 Page:372-376
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zou Yan¹,Chiu Hui¹,Zinovyeva Anna²,Ambros Victor²,Chuang Chiou-Fen¹,Chang Chieh¹³

Affiliation:

1. Division of Developmental Biology, Cincinnati Children's Hospital Research Foundation, Cincinnati, OH 45229, USA.

2. RNA Therapeutics Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.

3. Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 1B1, Canada.

Abstract

Turn Off Youth Our neurons regenerate better when we are young than when we are more mature. Studying the mechanosensory anterior ventral microtubule (AVM) neuron of the nematode Caenorhabditis elegans , Zou et al. (p. 372 ; see the Perspective by Nix and Bastiani ) found that worms lacking microRNA machinery had unusually robust axon regeneration and youthful-looking growth cones. Under- and overexpression of let-7 microRNA confirmed its involvement in depressing axon regeneration.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference23 articles.

1. C. elegansas a genetic model to identify novel cellular and molecular mechanisms underlying nervous system regeneration

2. Caenorhabditis elegans neuronal regeneration is influenced by life stage, ephrin signaling, and synaptic branching

3. Distinct cellular and molecular mechanisms mediate initial axon development and adult-stage axon regeneration in C. elegans

4. Axon Regeneration Requires a Conserved MAP Kinase Pathway

5. Amacrine-Signaled Loss of Intrinsic Axon Growth Ability by Retinal Ganglion Cells

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