Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system-Reference-Cited by-同舟云学术

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

Published:2016-06-10 Issue:6291 Volume:352 Page:1326-1329
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Marques Sueli¹,Zeisel Amit¹,Codeluppi Simone¹²,van Bruggen David¹,Mendanha Falcão Ana¹,Xiao Lin³⁴,Li Huiliang³,Häring Martin¹,Hochgerner Hannah¹,Romanov Roman A.¹⁵,Gyllborg Daniel¹,Muñoz-Manchado Ana B.¹,La Manno Gioele¹,Lönnerberg Peter¹,Floriddia Elisa M.¹,Rezayee Fatemah¹,Ernfors Patrik¹,Arenas Ernest¹,Hjerling-Leffler Jens¹,Harkany Tibor¹⁵,Richardson William D.³,Linnarsson Sten¹,Castelo-Branco Gonçalo¹

Affiliation:

1. Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden.

2. Department of Physiology and Pharmacology, Karolinska Institutet, SE-17177 Stockholm, Sweden.

3. Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK.

4. Institute of Neuroscience, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China.

5. Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.

Abstract

One size does not fit all Oligodendrocytes are best known for their ability to myelinate brain neurons, thus increasing the speed of signal transmission. Marques et al. surveyed oligodendrocytes of developing mice and found unexpected heterogeneity. Transcriptional analysis identified 12 populations, ranging from precursors to mature oligodendrocytes. Transcriptional profiles diverged as the oligodendrocytes matured, building distinct populations. One population was responsive to motor learning, and another, with a different transcriptome, traveled along blood vessels. Science , this issue p. 1326

Funder

Swedish Research Council

Swedish Cancer Society

Wallenberg Scholar

Söderberg Foundation

Linnaeus Center in Developmental Biology for Regenerative Medicine

Swedish Foundation for Strategic Research

European Union (EU)

Karolinska Institutet

EU FP7

Petrus and Augusta Hedlunds Foundation

Novo Nordisk Foundation

European Research Council (ERC)

National Natural Science Foundation of China

UK Biotechnology and Biological Sciences Research Council

Human Frontier Science Program

ERC

Wellcome Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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