Legionella Effectors That Promote Nonlytic Release from Protozoa-Reference-Cited by-同舟云学术

Legionella Effectors That Promote Nonlytic Release from Protozoa

Published:2004-02-27 Issue:5662 Volume:303 Page:1358-1361
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chen John¹²³⁴⁵,de Felipe Karim Suwwan¹²³⁴⁵,Clarke Margaret¹²³⁴⁵,Lu Hao¹²³⁴⁵,Anderson O. Roger¹²³⁴⁵,Segal Gil¹²³⁴⁵,Shuman Howard A.¹²³⁴⁵

Affiliation:

1. Department of Microbiology, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, NY 10032, USA.

2. Integrated Program in Cellular, Molecular and Biophysical Studies, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, NY 10032, USA.

3. Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City, OK 73104–5046, USA.

4. Department of Biology, Lamont-Doherty Earth Observatory, Columbia University, 61 Route 9W, Palisades, NY 10964–1000, USA.

5. Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Ramat-Aviv, Tel-Aviv 69978, Israel.

Abstract

Legionella pneumophila , the bacterial agent of legionnaires' disease, replicates intracellularly within a specialized vacuole of mammalian and protozoan host cells. Little is known about the specialized vacuole except that the Icm/Dot type IVsecretion system is essential for its formation and maintenance. The Legionella genome database contains two open reading frames encoding polypeptides (LepA and LepB) with predicted coiled-coil regions and weak homology to SNAREs; these are delivered to host cells by an Icm/Dot–dependent mechanism. Analysis of mutant strains suggests that the Lep proteins may enable the Legionella to commandeer a protozoan exocytic pathway for dissemination of the pathogen.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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