Structural Observation of the Primary Isomerization in Vision with Femtosecond-Stimulated Raman

Author:

Kukura Philipp1,McCamant David W.1,Yoon Sangwoon1,Wandschneider Daniel B.1,Mathies Richard A.1

Affiliation:

1. Department of Chemistry, University of California, Berkeley, CA 94720, USA.

Abstract

The primary event that initiates vision is the light-induced 11-cis to all-trans isomerization of retinal in the visual pigment rhodopsin. Despite decades of study with the traditional tools of chemical reaction dynamics, both the timing and nature of the atomic motions that lead to photoproduct production remain unknown. We used femtosecond-stimulated Raman spectroscopy to obtain time-resolved vibrational spectra of the molecular structures formed along the reaction coordinate. The spectral evolution of the vibrational features from 200 femtoseconds to 1 picosecond after photon absorption reveals the temporal sequencing of the geometric changes in the retinal backbone that activate this receptor.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

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