Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens-Reference-Cited by-同舟云学术

Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens

Published:2017-04-21 Issue:6335 Volume:356 Page:315-319
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kim Yun-Gi¹²^ORCID,Sakamoto Kei¹²^ORCID,Seo Sang-Uk¹²,Pickard Joseph M.¹²,Gillilland Merritt G.³^ORCID,Pudlo Nicholas A.⁴^ORCID,Hoostal Matthew³^ORCID,Li Xue³,Wang Thomas D.⁵^ORCID,Feehley Taylor⁶,Stefka Andrew T.⁶,Schmidt Thomas M.³⁴^ORCID,Martens Eric C.⁴^ORCID,Fukuda Shinji⁷⁸,Inohara Naohiro¹^ORCID,Nagler Cathryn R.⁶^ORCID,Núñez Gabriel¹²^ORCID

Affiliation:

1. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

2. Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

3. Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

4. Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

5. Departments of Biomedical Engineering and Mechanical Engineering, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

6. Department of Pathology and Committee on Immunology, University of Chicago, Chicago, IL 60637, USA.

7. Institute for Advanced Biosciences, Keio University, Yamagata, Japan.

8. PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan.

Abstract

Gut anaerobes protect against pathogen invasion Intestinal infections are a common problem for young animals. One explanation is that the protective gut microbiota is not fully established in infants. How the microbiota might protect against pathogens is unclear. Kim et al. found that members of the group of strictly anaerobic, spore-forming bacteria known as clostridia protect neonatal mice against diarrhea-causing pathogens. The protective effect is enhanced by giving mice the metabolite succinate in drinking water. Succinate favors colonization of the neonatal gut by cluster IV and XIVa clostridia and concomitantly excludes Salmonella typhimurium. Science , this issue p. 315

Funder

National Institutes of Health

Foundation for the National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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