Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues-Reference-Cited by-同舟云学术

Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues

Published:2021-05-14 Issue:6543 Volume:372 Page:738-741
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Yang Fan¹^ORCID,Nielsen Sandra C. A.¹^ORCID,Hoh Ramona A.¹^ORCID,Röltgen Katharina¹^ORCID,Wirz Oliver Fabian¹^ORCID,Haraguchi Emily¹,Jean Grace H.¹^ORCID,Lee Ji-Yeun¹^ORCID,Pham Tho D.¹²,Jackson Katherine J. L.³^ORCID,Roskin Krishna M.⁴⁵⁶^ORCID,Liu Yi⁷^ORCID,Nguyen Khoa¹^ORCID,Ohgami Robert S.⁸^ORCID,Osborne Eleanor M.⁹,Nadeau Kari C.¹⁰¹¹^ORCID,Niemann Claus U.¹²¹³^ORCID,Parsonnet Julie¹⁴¹⁵^ORCID,Boyd Scott D.¹¹⁰^ORCID

Affiliation:

1. Department of Pathology, Stanford University, Stanford, CA 94305, USA.

2. Stanford Blood Center, Stanford University, Stanford, CA 94305, USA.

3. Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.

4. Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45267, USA.

5. Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

6. Division of Immunobiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

7. Calico Life Sciences, South San Francisco, CA 94080, USA.

8. Department of Pathology, University of California, San Francisco, CA 94143, USA.

9. Sarah Cannon Cancer Center, Tennessee Oncology, Smyrna, TN 37167, USA.

10. Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, CA 94305, USA.

11. Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA 94305, USA.

12. Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143, USA.

13. Department of Surgery, Division of Transplantation, University of California, San Francisco, CA 94143, USA.

14. Department of Medicine, Stanford University, Stanford, CA 94305, USA.

15. Epidemiology and Population Health, Stanford University, Stanford, CA 94305, USA.

Abstract

Kids armed with anti-coronavirus B cells It remains unclear whether B cell repertoires against coronaviruses and other pathogens differ between adults and children and how important these distinctions are. Yang et al. analyzed blood samples from young children and adults, as well as tissues from deceased organ donors, characterizing the B cell receptor (BCR) repertoires specific to six common pathogens and two viruses that they had not seen before: Ebola virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Children had higher frequencies of B cells with convergent BCR heavy chains against previously encountered pathogens and higher frequencies of class-switched convergent B cell clones against SARS-CoV-2 and related coronaviruses. These findings suggest that encounters with coronaviruses in early life may produce cross-reactive memory B cell populations that contribute to divergent COVID-19 susceptibilities. Science , this issue p. 738

Funder

National Cancer Institute

National Institute of Allergy and Infectious Diseases

Crown Family Foundation

This

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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