Efficacy of inactivated poliovirus vaccine in India-Reference-Cited by-同舟云学术

Efficacy of inactivated poliovirus vaccine in India

Published:2014-08-22 Issue:6199 Volume:345 Page:922-925
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Jafari Hamid¹,Deshpande Jagadish M.²,Sutter Roland W.³,Bahl Sunil¹,Verma Harish³,Ahmad Mohammad¹,Kunwar Abhishek¹,Vishwakarma Rakesh¹,Agarwal Ashutosh¹,Jain Shilpi⁴,Estivariz Concepcion⁵,Sethi Raman¹,Molodecky Natalie A.³,Grassly Nicholas C.⁶,Pallansch Mark A.⁵,Chatterjee Arani⁴,Aylward R. Bruce³

Affiliation:

1. World Health Organization, India-National Polio Surveillance Project, R. K. Khanna Stadium, Africa Avenue, Safdarjung Enclave, New Delhi 110029, India.

2. Enterovirus Research Center, Haffkine Institute Compound, Parel, Mumbai, India.

3. World Health Organization, Ave Appia, Geneva, Switzerland.

4. Panacea Biotec Ltd., New Delhi, India.

5. Centers for Disease Control and Prevention, Atlanta, GA, USA.

6. Department of Infectious Disease Epidemiology, Imperial College London, London, UK.

Abstract

Two vaccines together are better than one alone Polio is proving difficult to eradicate. Making the choice between administering a live attenuated vaccine orally (Sabin) or an inactivated vaccine (Salk) by injection has been highly controversial. Patients prefer the Sabin vaccine, but it requires many doses to offer immunity. Jafari et al. tested the two vaccines together in northern India. The injected vaccine significantly reduced virus shedding and boosted intestinal mucosal immunity in children already given the oral vaccine. Thus, using both vaccines could help speed the eventual global demise of polio. Science , this issue p. 922

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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