A Targeting Motif Involved in Sodium Channel Clustering at the Axonal Initial Segment

Author:

Garrido Juan José1,Giraud Pierre1,Carlier Edmond1,Fernandes Fanny1,Moussif Anissa1,Fache Marie-Pierre1,Debanne Dominique1,Dargent Bénédicte1

Affiliation:

1. Institut National de la Santé et de la Recherche Médicale Unité 464, Institut Jean Roche, Université de la Méditerranée, Faculté de Médecine Secteur-Nord, Boulevard P. Dramard, 13916 Marseille Cedex 20, France.

Abstract

The sorting of sodium channels to axons and the formation of clusters are of primary importance for neuronal electrogenesis. Here, we showed that the cytoplasmic loop connecting domains II and III of the Na v 1 subunit contains a determinant conferring compartmentalization in the axonal initial segment of rat hippocampal neurons. Expression of a soluble Na v 1.2II-III linker protein led to the disorganization of endogenous sodium channels. The motif was sufficient to redirect a somatodendritic potassium channel to the axonal initial segment, a process involving association with ankyrin G. Thus, this motif may play a fundamental role in controlling electrical excitability during development and plasticity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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