Invertible promoters mediate bacterial phase variation, antibiotic resistance, and host adaptation in the gut-Reference-Cited by-同舟云学术

Invertible promoters mediate bacterial phase variation, antibiotic resistance, and host adaptation in the gut

Published:2019-01-11 Issue:6423 Volume:363 Page:181-187
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Jiang Xiaofang¹²^ORCID,Hall A. Brantley²³^ORCID,Arthur Timothy D.²^ORCID,Plichta Damian R.²³^ORCID,Covington Christian T.²³^ORCID,Poyet Mathilde¹²⁴^ORCID,Crothers Jessica⁵,Moses Peter L.⁶^ORCID,Tolonen Andrew C.²³^ORCID,Vlamakis Hera²³^ORCID,Alm Eric J.¹²⁴^ORCID,Xavier Ramnik J.¹²³⁷^ORCID

Affiliation:

1. Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

3. Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

4. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

5. Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT 05401, USA.

6. Division of Gastroenterology and Hepatology, University of Vermont, Burlington, VT 05401, USA.

7. Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Abstract

Switching ON resistance Clonal bacterial colonies will often grow dissimilar patches, similar to a tortoiseshell pattern. These differing phenotypes arise by reversible mechanisms called phase variation. Jiang et al. developed an algorithm to survey bacterial genomes for invertible promoters that cause phase variation. Inverted repeats signal the presence of these promoters, which can flip between ON and OFF states catalyzed by phage integrase analogs called invertases. Invertible promoters linked to antibiotic resistance genes were widespread among vertebrate gut–associated organisms, including Bacteroidetes, Spirochaetes, and Verrucomicrobia. These bacteria are thus equipped and prepared for sudden environmental stress, including antibiotic exposure. Science , this issue p. 181

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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