Evolution and host-specific adaptation of <i>Pseudomonas aeruginosa</i>-Reference-Cited by-同舟云学术

Evolution and host-specific adaptation of Pseudomonas aeruginosa

Published:2024-07-05 Issue:6704 Volume:385 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Weimann Aaron¹²³⁴^ORCID,Dinan Adam M.¹²³^ORCID,Ruis Christopher¹²³⁴^ORCID,Bernut Audrey⁵^ORCID,Pont Stéphane⁵^ORCID,Brown Karen¹²⁶^ORCID,Ryan Judy¹²,Santos Lúcia⁷^ORCID,Ellison Louise²^ORCID,Ukor Emem²⁶^ORCID,Pandurangan Arun P.¹⁸⁹^ORCID,Krokowski Sina¹²,Blundell Tom L.¹⁸⁹^ORCID,Welch Martin⁸^ORCID,Blane Beth⁹^ORCID,Judge Kim¹⁰,Bousfield Rachel⁹¹¹^ORCID,Brown Nicholas¹¹^ORCID,Bryant Josephine M.¹⁰,Kukavica-Ibrulj Irena¹²^ORCID,Rampioni Giordano¹³¹⁴^ORCID,Leoni Livia¹³^ORCID,Harrison Patrick T.⁷^ORCID,Peacock Sharon J.⁹¹¹^ORCID,Thomson Nicholas R.¹⁰¹⁵^ORCID,Gauthier Jeff¹²^ORCID,Fothergill Jo L.¹⁶^ORCID,Levesque Roger C.¹²^ORCID,Parkhill Julian⁴^ORCID,Floto R. Andres¹²³⁶⁹^ORCID

Affiliation:

1. Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge, UK.

2. University of Cambridge Molecular Immunity Unit, MRC Laboratory of Molecular Biology, Cambridge, UK.

3. Cambridge Centre for AI in Medicine, University of Cambridge, Cambridge, UK.

4. Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

5. Laboratory of Pathogens and Host Immunity (LPHI), UMR5235, CNRS/Université de Montpellier, Montpellier, France.

6. Cambridge Centre for Lung Infection, Royal Papworth Hospital, Cambridge, UK.

7. Department of Physiology, Bioscience Institute, University College Cork, Cork, Ireland.

8. Department of Biochemistry, University of Cambridge, Cambridge, UK.

9. Department of Medicine, University of Cambridge, Cambridge, UK.

10. Wellcome Sanger Institute, Hinxton, UK.

11. Cambridge University Hospitals Trust, Cambridge, UK.

12. Institut de Biologie Intégrative et des Systèmes (IBIS), Université Laval, Québec City, Québec, Canada.

13. Department of Science, University Roma Tre, Rome, Italy.

14. IRCCS Fondazione Santa Lucia, Rome, Italy.

15. London School of Hygiene and Tropical Medicine, London, UK.

16. Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool, UK.

Abstract

The major human bacterial pathogen Pseudomonas aeruginosa causes multidrug-resistant infections in people with underlying immunodeficiencies or structural lung diseases such as cystic fibrosis (CF). We show that a few environmental isolates, driven by horizontal gene acquisition, have become dominant epidemic clones that have sequentially emerged and spread through global transmission networks over the past 200 years. These clones demonstrate varying intrinsic propensities for infecting CF or non-CF individuals (linked to specific transcriptional changes enabling survival within macrophages); have undergone multiple rounds of convergent, host-specific adaptation; and have eventually lost their ability to transmit between different patient groups. Our findings thus explain the pathogenic evolution of P. aeruginosa and highlight the importance of global surveillance and cross-infection prevention in averting the emergence of future epidemic clones.

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://www.science.org/doi/pdf/10.1126/science.adi0908

Reference105 articles.

1. PSEUDOMONAS ÆRUGINOSA CONTAMINATION IN DOMESTIC AND HOSPITAL ENVIRONMENTS

2. Agricultural Plants and Soil as a Reservoir for Pseudomonas aeruginosa

3. Global Pseudomonas aeruginosa biodiversity as reflected in a Belgian river

4. A STUDY OF THE INCIDENCE OF PSEUDOMONAS AERUGINOSA FROM VARIOUS NATURAL SOURCES

5. The environmental occurrence of Pseudomonas aeruginosa

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. ‘Wild Type’;Microbiology;2024-08-30

2. Mucin adhesion of serial cystic fibrosis airways Pseudomonas aeruginosa isolates;Frontiers in Cellular and Infection Microbiology;2024-08-22