RTEL-1 Enforces Meiotic Crossover Interference and Homeostasis-Reference-Cited by-同舟云学术

RTEL-1 Enforces Meiotic Crossover Interference and Homeostasis

Published:2010-03-05 Issue:5970 Volume:327 Page:1254-1258
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Youds Jillian L.¹,Mets David G.²,McIlwraith Michael J.³,Martin Julie S.¹,Ward Jordan D.¹,ONeil Nigel J.⁴,Rose Ann M.⁴,West Stephen C.³,Meyer Barbara J.²,Boulton Simon J.¹

Affiliation:

1. DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms, EN6 3LD, UK.

2. Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 97420, USA.

3. Genetic Recombination Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms, EN6 3LD, UK.

4. Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.

Abstract

Managing Crossovers In all sexual eukaryotes a special type of cell division called meiosis produces gametes or spores. For chromosomes to segregate properly to the daughter cells during meiosis, DNA crossovers must occur between every pair of homologous chromosomes. The position and number of these crossovers, which help to hold the homologous chromosomes together, is carefully controlled, in part by the condensin I complex. Youds et al. (p. 1254 ) show that in the nematode, Caenorhabditis elegans , crossovers are regulated at a second level by the anti-recombinase RTEL-1 (regulator of telomere elongation helicase–1). RTEL-1 prevents crossovers occurring too close to each other, and ensures that only one occurs per pair of homologous chromosomes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference16 articles.

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