Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic-Reference-Cited by-同舟云学术

Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic

Published:2020-08-21 Issue:6506 Volume:369 Page:993-999
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chin Emily N.¹^ORCID,Yu Chenguang¹²^ORCID,Vartabedian Vincent F.³,Jia Ying¹³,Kumar Manoj²,Gamo Ana M.²^ORCID,Vernier William²,Ali Sabrina H.¹,Kissai Mildred¹,Lazar Daniel C.³^ORCID,Nguyen Nhan³^ORCID,Pereira Laura E.¹^ORCID,Benish Brent²,Woods Ashley K.²,Joseph Sean B.²^ORCID,Chu Alan²^ORCID,Johnson Kristen A.²^ORCID,Sander Philipp N.¹^ORCID,Martínez-Peña Francisco¹^ORCID,Hampton Eric N.²^ORCID,Young Travis S.²^ORCID,Wolan Dennis W.⁴^ORCID,Chatterjee Arnab K.²,Schultz Peter G.¹²^ORCID,Petrassi H. Michael²^ORCID,Teijaro John R.³^ORCID,Lairson Luke L.¹^ORCID

Affiliation:

1. Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

2. California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA.

3. Department of Immunology and Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

4. Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference34 articles.

1. Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

2. Viral evasion of DNA-stimulated innate immune responses

3. cGAS surveillance of micronuclei links genome instability to innate immunity

4. Mitotic progression following DNA damage enables pattern recognition within micronuclei

5. L1 drives IFN in senescent cells and promotes age-associated inflammation

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