Comment on "Large-Scale Sequence Analysis of Avian Influenza Isolates"-Reference-Cited by-同舟云学术

Comment on "Large-Scale Sequence Analysis of Avian Influenza Isolates"

Published:2006-09-15 Issue:5793 Volume:313 Page:1573-1573
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Holmes Edward C.¹²³⁴,Lipman David J.¹²³⁴,Zamarin Dmitriy¹²³⁴,Yewdell Jonathan W.¹²³⁴

Affiliation:

1. Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, PA 16802, USA.

2. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.

3. Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA.

4. Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Obenauer et al . (Research Articles, 17 March 2006, p. 1576) reported that the influenza A virus PB1-F2 gene is evolving under strong positive selection, as documented by an extremely high ratio of the number of nonsynonymous nucleotide substitutions to the number of synonymous substitutions (dN/dS). However, we show that this observation is likely to be an artifact related to the location of PB1-F2 in the +1 reading frame of the PB1 gene.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference4 articles.

1. Large-Scale Sequence Analysis of Avian Influenza Isolates

2. A Dependent-Rates Model and an MCMC-Based Methodology for the Maximum-Likelihood Analysis of Sequences with Overlapping Reading Frames

3. HyPhy: hypothesis testing using phylogenies

4. Evolution and ecology of influenza A viruses

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