A Microfluidic Device for Conducting Gas-Liquid-Solid Hydrogenation Reactions-Reference-Cited by-同舟云学术

A Microfluidic Device for Conducting Gas-Liquid-Solid Hydrogenation Reactions

Published:2004-05-28 Issue:5675 Volume:304 Page:1305-1308
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kobayashi Juta¹²,Mori Yuichiro¹²,Okamoto Kuniaki¹²,Akiyama Ryo¹²,Ueno Masaharu¹²,Kitamori Takehiko¹²,Kobayashi Shū¹²

Affiliation:

1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

2. Department of Applied Chemistry, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

Abstract

We have developed an efficient system for triphase reactions using a microchannel reactor. Using this system, we conducted hydrogenation reactions that proceeded smoothly to afford the desired products quantitatively within 2 minutes for a variety of substrates. The system could also be applied to deprotection reactions. We could achieve an effective interaction between hydrogen, substrates, and a palladium catalyst using extremely large interfacial areas and the short path required for molecular diffusion in the very narrow channel space. This concept could be extended to other multiphase reactions that use gas-phase reagents such as oxygen and carbon dioxide.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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