Yeast Life-Span Extension by Calorie Restriction Is Independent of NAD Fluctuation-Reference-Cited by-同舟云学术

Yeast Life-Span Extension by Calorie Restriction Is Independent of NAD Fluctuation

Published:2003-12-19 Issue:5653 Volume:302 Page:2124-2126
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Anderson Rozalyn M.¹²³,Latorre-Esteves Magda¹²³,Neves Ana Rute¹²³,Lavu Siva¹²³,Medvedik Oliver¹²³,Taylor Christopher¹²³,Howitz Konrad T.¹²³,Santos Helena¹²³,Sinclair David A.¹²³

Affiliation:

1. Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston MA 02115, USA.

2. Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Rua da Quinta Grande 6, Apartado 127, 2780-156 OEIRAS, Portugal.

3. Biomol Research Laboratories, Inc., 5120 Butler Pike, Plymouth Meeting, PA 19462, USA.

Abstract

Calorie restriction (CR) slows aging in numerous species. In the yeast Saccharomyces cerevisiae , this effect requires Sir2, a conserved NAD + -dependent deacetylase. We report that CR reduces nuclear NAD + levels in vivo. Moreover, the activity of Sir2 and its human homologue SIRT1 are not affected by physiological alterations in the NAD + :NADH ratio. These data implicate alternate mechanisms of Sir2 regulation by CR.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference25 articles.

1. Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

2. High Osmolarity Extends Life Span in Saccharomyces cerevisiae by a Mechanism Related to Calorie Restriction

3. An intervention resembling caloric restriction prolongs life span and retards aging in yeast

4. Effect of stress on the life span of the yeast Saccharomyces cerevisiae.

5. A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family

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