Affiliation:
1. School of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK.
Abstract
wingless
and
decapentaplegic
signaling establishes the proximal-distal axis of
Drosophila
legs by activating the expression of genes such as
Distalless
and
dachshund
in broad proximal-distal domains during early leg development. However, here we show that
wingless
and
decapentaplegic
are not required throughout all of proximal-distal development. The tarsus, which has been proposed to be an ancestral structure, is instead defined by the activity of
Distalless
,
dachshund
, and a distal gradient of epidermal growth factor receptor (EGFR)–Ras signaling. Our results uncover a mechanism for appendage patterning directed by genes expressed in proximal-distal domains and possibly conserved in other arthropods and vertebrates.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
148 articles.
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