Tudor-SN–mediated endonucleolytic decay of human cell microRNAs promotes G 1 /S phase transition-Reference-Cited by-全球学者库

Tudor-SN–mediated endonucleolytic decay of human cell microRNAs promotes G 1 /S phase transition

Published:2017-05-26 Issue:6340 Volume:356 Page:859-862
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Elbarbary Reyad A.¹²^ORCID,Miyoshi Keita¹²^ORCID,Myers Jason R.³^ORCID,Du Peicheng⁴^ORCID,Ashton John M.³^ORCID,Tian Bin⁵^ORCID,Maquat Lynne E.¹²⁶^ORCID

Affiliation:

1. Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA.

2. Center for RNA Biology, University of Rochester, Rochester, NY 14642, USA.

3. Genomics Research Center, University of Rochester, Rochester, NY 14642, USA.

4. Office of Advanced Research Computing, Rutgers University, Piscataway, NJ 08854, USA.

5. Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.

6. Department of Oncology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA.

Abstract

Breaking down miRNAs Although much work has examined microRNA (miRNA) biogenesis, relatively little is known about miRNA decay. Elbarbary et al. now identify Tudor-SN, an endonuclease that interacts with the RNA-induced silencing complex. Tudor-SN targets miRNAs at CA and UA dinucleotides located more than five nucleotides from miRNA ends. Tudor-SN-mediated miRNA decay removes miRNAs that silence genes encoding proteins that are critical for the G 1 -to-S phase transition in the cell cycle. Science , this issue p. 859

Funder

National Institutes of Health

Uehara Memorial Foundation

Mochida Memorial Foundation for Medical and Pharmaceutical Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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