Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I-Reference-Cited by-同舟云学术

Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I

Published:2011-06-24 Issue:6037 Volume:332 Page:1561-1564
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kim Nayun¹,Huang Shar-yin N.²,Williams Jessica S.³,Li Yue C.¹,Clark Alan B.³,Cho Jang-Eun¹,Kunkel Thomas A.³,Pommier Yves²,Jinks-Robertson Sue¹

Affiliation:

1. Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.

2. Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

3. Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

Abstract

An enzyme that removes supercoils from DNA can cause mutations when RNA bases accidentally get incorporated into the DNA.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference24 articles.

1. Genome instability due to ribonucleotide incorporation into DNA

2. Mismatch repair-independent tandem repeat sequence instability resulting from ribonucleotide incorporation by DNA polymerase ɛ

3. Role for topoisomerase 1 in transcription-associated mutagenesis in yeast

4. Topoisomerase 1 provokes the formation of short deletions in repeated sequences upon high transcription in Saccharomyces cerevisiae

5. Cellular roles of DNA topoisomerases: a molecular perspective

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