Microtubules acquire resistance from mechanical breakage through intralumenal acetylation-Reference-Cited by-同舟云学术

Microtubules acquire resistance from mechanical breakage through intralumenal acetylation

Published:2017-04-21 Issue:6335 Volume:356 Page:328-332
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Xu Zhenjie¹²^ORCID,Schaedel Laura³,Portran Didier¹^ORCID,Aguilar Andrea¹^ORCID,Gaillard Jérémie³^ORCID,Marinkovich M. Peter²⁴,Théry Manuel³⁵^ORCID,Nachury Maxence V.¹^ORCID

Affiliation:

1. Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305-5345, USA.

2. Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305-5168, USA.

3. CytoMorpho Laboratory, Laboratory of Cell and Plant Physiology (LPCV), UMR 5168, Biosciences and Biotechnology Institute of Grenoble, CEA/INRA/CNRS/Université Grenoble-Alpes, 17 rue des Martyrs, 38054 Grenoble, France.

4. Division of Dermatology, Palo Alto Veterans Affairs Medical Center, Palo Alto, CA 94305, USA.

5. CytoMorpho Laboratory, A2T, UMRS 1160, Institut Universitaire d’Hématologie, Hôpital Saint Louis, INSERM/AP-HP/Université Paris Diderot, 1 Avenue Claude Vellefaux, 75010 Paris, France.

Abstract

Acetylation keeps microtubules strong Cells need microtubules for intracellular transport and to avoid being crushed. On investigating microtubule breakage in live fibroblasts, Xu et al. found that if they were not acetylated, long-lived microtubules underwent frequent rupture after buckling. Acetylation makes microtubules more mechanically stable, facilitates sliding between filaments, and makes the lattice more plastic. Science , this issue p. 328

Funder

U.S. Department of Defense

National Cancer Institute

National Institute of General Medical Sciences

European Research Council

Agence Nationale de la Recherche

Human Frontier Science Program

Stanford Dean’s Postdoctoral Fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary