Angiotensin II Type 2 Receptor Signaling Attenuates Aortic Aneurysm in Mice Through ERK Antagonism-Reference-Cited by-同舟云学术

Angiotensin II Type 2 Receptor Signaling Attenuates Aortic Aneurysm in Mice Through ERK Antagonism

Published:2011-04-15 Issue:6027 Volume:332 Page:361-365
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Habashi Jennifer P.¹²,Doyle Jefferson J.¹,Holm Tammy M.¹,Aziz Hamza¹,Schoenhoff Florian¹,Bedja Djahida³,Chen YiChun¹,Modiri Alexandra N.¹,Judge Daniel P.⁴,Dietz Harry C.¹²⁴

Affiliation:

1. Howard Hughes Medical Institute and Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

2. Division of Pediatric Cardiology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

3. Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

4. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

Transforming growth factor–β promotes aortic aneurysm formation through activation of its “noncanonical” signaling pathway.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference22 articles.

1. Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome

2. Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome

3. TGF-β–dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome

4. Angiotensin II type 1 receptor blockade attenuates TGF-β–induced failure of muscle regeneration in multiple myopathic states

5. Angiotensin II stimulates expression of transforming growth factor β receptor type II in cultured mouse proximal tubular cells

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