Genetic Mapping in Human Disease-Reference-Cited by-同舟云学术

Genetic Mapping in Human Disease

Published:2008-11-07 Issue:5903 Volume:322 Page:881-888
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Altshuler David¹²³⁴⁵,Daly Mark J.¹²³⁴⁵,Lander Eric S.¹²³⁴⁵

Affiliation:

1. Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

2. Center for Human Genetic Research and Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.

3. Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

4. Department of Genetics, Harvard Medical School, Boston, MA 02114, USA.

5. Department of Medicine, Harvard Medical School, Boston, MA 02114, USA.

Abstract

Genetic mapping provides a powerful approach to identify genes and biological processes underlying any trait influenced by inheritance, including human diseases. We discuss the intellectual foundations of genetic mapping of Mendelian and complex traits in humans, examine lessons emerging from linkage analysis of Mendelian diseases and genome-wide association studies of common diseases, and discuss questions and challenges that lie ahead.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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