Affiliation:
1. Institute for Stem Cell Biology and Regenerative Medicine, Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
2. Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
3. Ludwig Center for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Abstract
Fibroblasts in fibrosis
Excess fibrous connective tissue, similar to scarring, forms during the repair of injuries. Fibroblasts are known to be involved, but their role is poorly characterized. Rinkevich
et al.
identify two lineages of dermal fibroblasts in the dorsal skin of mice (see the Perspective by Sennett and Rendl). A fibrogenic lineage, defined by embryonic expression of
Engrailed-1
, plays a central role in dermal development, wound healing, radiation-induced fibrosis, and cancer stroma formation. Targeted inhibition of this lineage results in reduced melanoma growth and scar formation, with no effect on the structural integrity of the healed skin, thus indicating therapeutic approaches for treating fibrotic disease.
Science
, this issue
10.1126/science.aaa2151
; see also p.
284
Funder
NIH
National Institute of General Medical Sciences
California Institute for Regenerative Medicine
The Oak Foundation
Plastic Surgery Foundation
Human Frontier Science Program
Virginia and D. K. Ludwig Fund for Cancer Research
Stanford School of Medicine
California Institute of Regenerative Medicine
Smith Family Trust
Hagey Laboratory for Pediatric Regenerative Medicine
Gunn/Olivier fund
Stanford Medical Scientist Training Program
Machiah Foundation Fellowship
Siebel Scholarship
Translational Research and Applied Medicine
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
505 articles.
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