Evidence for Autoregulation of Cystathionine γ-Synthase mRNA Stability in Arabidopsis-Reference-Cited by-同舟云学术

Evidence for Autoregulation of Cystathionine γ-Synthase mRNA Stability in Arabidopsis

Published:1999-11-12 Issue:5443 Volume:286 Page:1371-1374
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chiba Yukako¹,Ishikawa Mari¹,Kijima Fumiko¹,Tyson R. Huw²,Kim Jungsup³,Yamamoto Ayako¹,Nambara Eiji¹,Leustek Thomas³,Wallsgrove Roger M.²,Naito Satoshi¹

Affiliation:

1. Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan.

2. Biochemistry and Physiology Department, IACR-Rothamsted, Harpenden, Hartfordshire AL5 2JQ, United Kingdom.

3. Biotechnology Center for Agriculture and the Environment, Rutgers University, New Brunswick, NJ 08901–8520, USA.

Abstract

Control of messenger RNA (mRNA) stability serves as an important mechanism for regulating gene expression. Analysis of Arabidopsis mutants that overaccumulate soluble methionine (Met) revealed that the gene for cystathionine γ-synthase (CGS), the key enzyme in Met biosynthesis, is regulated at the level of mRNA stability. Transfection experiments with wild-type and mutant forms of the CGS gene suggest that an amino acid sequence encoded by the first exon of CGS acts in cis to destabilize its own mRNA in a process that is activated by Met or one of its metabolites.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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