Affiliation:
1. Center for RNA Research, Institute for Basic Science, Seoul 151-742, Republic of Korea.
2. School of Biological Sciences, Seoul National University, Seoul 151-742, Republic of Korea.
Abstract
A tale of not-so-pure tails
The poly(A) tail of mRNA has been thought to be a pure stretch of adenosine nucleotides with little informational content except for length. Lim
et al.
identified enzymes that can decorate poly(A) tails with non-A nucleotides. The noncanonical poly(A) polymerases, TENT4A and TENT4B, incorporate intermittent non-A residues (G, U, or C) with a preference for guanosine, which results in a heterogenous poly(A) tail. Deadenylases trim poly(A) tails to initiate mRNA degradation but stall at the non-A residues. In effect, the not-so-pure tail stabilizes mRNAs by slowing down deadenylation.
Science
, this issue p.
701
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
125 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献