Immune Hyperactivation of HIV-1-Infected T Cells Mediated by Tat and the CD28 Pathway-Reference-Cited by-同舟云学术

Immune Hyperactivation of HIV-1-Infected T Cells Mediated by Tat and the CD28 Pathway

Published:1997-03-07 Issue:5305 Volume:275 Page:1481-1485
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ott Melanie¹,Emiliani Stephane¹,Van Lint Carine¹,Herbein Georges¹,Lovett Jennie¹,Chirmule Narendra²,McCloskey Thomas²,Pahwa Savita²,Verdin Eric¹

Affiliation:

1. M. Ott, S. Emiliani, C. Van Lint, G. Herbein, J. Lovett, E. Verdin, The Picower Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA.

2. N. Chirmule, T. McCloskey, S. Pahwa, North Shore University Hospital and New York University School of Medicine, 350 Community Drive, Manhasset, NY 11030, USA.

Abstract

Human immunodeficiency virus-type 1 (HIV-1) infection is characterized by a chronic state of immune hyperactivation in patients. Infection of human peripheral blood lymphocytes with HIV-1 in vitro resulted in increased interleukin-2 (IL-2) secretion in response to T cell activation via the CD3 and CD28 receptors. Expression of the HIV-1 transactivator Tat recapitulated this phenotype and was associated with increased IL-2 secretion in response to costimulation with CD3 plus CD28. IL-2 superinduction by Tat occurred at the transcriptional level, was mediated by the CD28-responsive element in the IL-2 promoter, and was exclusively dependent on the 29 amino acids encoded by the second exon of Tat.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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