IgG antibodies to dengue enhanced for FcγRIIIA binding determine disease severity-Reference-Cited by-同舟云学术

IgG antibodies to dengue enhanced for FcγRIIIA binding determine disease severity

Published:2017-01-27 Issue:6323 Volume:355 Page:395-398
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Wang Taia T.¹²,Sewatanon Jaturong³⁴⁵,Memoli Matthew J.⁶,Wrammert Jens⁴⁷,Bournazos Stylianos¹,Bhaumik Siddhartha Kumar⁴⁷,Pinsky Benjamin A.²⁸,Chokephaibulkit Kulkanya⁹,Onlamoon Nattawat¹⁰,Pattanapanyasat Kovit¹⁰,Taubenberger Jeffery K.⁶,Ahmed Rafi³⁴,Ravetch Jeffrey V.¹

Affiliation:

1. Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

2. Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.

3. Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.

4. Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA.

5. Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand 10700.

6. Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

7. Division of Infectious Disease, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.

8. Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

9. Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand 10700.

10. Department of Research and Development, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand 10700.

Abstract

A rare ability to enhance dengue virus disease In some cases, secondary infections of dengue virus can be extremely serious and result in plasma leakage, thrombocytopenia, and hemorrhagic disease. This phenomenon has been attributed to antibody-dependent enhancement. Wang et al. show that a specific subclass of antibody, IgG1, which lacks fucosyl residues on the Fc segment of the heavy chain of the immunoglobulin, is elevated in patients with severe secondary dengue disease. These non-neutralizing antibodies bind activating Fc receptors and appear to cross-react with platelet antigens to cause platelet depletion, contributing to thrombocytopenia. Science , this issue p. 395

Funder

National Center for Advancing Translational Sciences

Clinical and Translational Science Award

NIH

American Foundation for AIDS Research Mathilde Krim Fellowship in Basic Biomedical Research

National Institute of Allergy and Infectious Diseases of the NIH

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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