Genetics of schizophrenia in the South African Xhosa-Reference-Cited by-同舟云学术

Genetics of schizophrenia in the South African Xhosa

Published:2020-01-31 Issue:6477 Volume:367 Page:569-573
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Gulsuner S.¹^ORCID,Stein D. J.²^ORCID,Susser E. S.³⁴^ORCID,Sibeko G.²^ORCID,Pretorius A.²,Walsh T.¹^ORCID,Majara L.⁵,Mndini M. M.²,Mqulwana S. G.²,Ntola O. A.²,Casadei S.¹^ORCID,Ngqengelele L. L.²^ORCID,Korchina V.⁶^ORCID,van der Merwe C.⁵^ORCID,Malan M.²^ORCID,Fader K. M.³^ORCID,Feng M.³⁴^ORCID,Willoughby E.⁷^ORCID,Muzny D.⁶^ORCID,Baldinger A.²^ORCID,Andrews H. F.³⁴,Gur R. C.⁸^ORCID,Gibbs R. A.⁶^ORCID,Zingela Z.⁹¹⁰^ORCID,Nagdee M.⁹¹⁰^ORCID,Ramesar R. S.⁵^ORCID,King M.-C.¹^ORCID,McClellan J. M.¹^ORCID

Affiliation:

1. Department of Medicine, Department of Genome Sciences, and Department of Psychiatry, University of Washington, Seattle, WA, USA.

2. Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.

3. Mailman School of Public Health, Columbia University, New York, NY, USA.

4. New York State Psychiatric Institute, New York, NY, USA.

5. Division of Human Genetics, University of Cape Town, Cape Town, South Africa.

6. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.

7. Department of Psychology, University of Minnesota, Minneapolis, MN, USA.

8. Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.

9. Department of Psychology, Rhodes University, Makhanda (Grahamstown), South Africa.

10. Department of Psychiatry and Human Behavioral Sciences, Walter Sisulu University, Mthatha, South Africa.

Abstract

African schizophrenia genetic variants The genetics of schizophrenia have predominately been studied in populations of European and Asian descent. However, studies in Africans, who host the greatest degree of human genetic diversity, have lagged. Examining the exomes of more than 1800 Xhosa individuals from South Africa, about half of which have been diagnosed with schizophrenia, Gulsuner et al. identified both rare and common genetic variants associated with the disease. They found that the genetic architecture of schizophrenia in Africans generally reflects that of Europeans but that the greater genetic variation in Africa provides more power to detect relationships of genes to phenotypes. Science , this issue p. 569

Funder

National Institutes of Health

Brain and Behavior Research Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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