Affiliation:
1. Gene Expression Programme, European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, 69117 Heidelberg, Germany.
Abstract
Putting the Sugar on Polycomb
A wide variety of nuclear and cytosolic proteins in human cells carry an O-linked sugar modification,
N
-acetylglucosamine (GlcNAc), which is added by the highly conserved O-linked GlcNAc transferase, Ogt.
Gambetta
et al.
(p.
93
, published online 28 May; see the Perspective by
Simon
) show that in
Drosophila
, Ogt is encoded by super sex combs, a classic Polycomb group gene known for its role in repressing developmental regulator genes. GlcNAc modification is highly enriched at chromosomal sites bound by Polycomb group proteins, and one of these, Polyhomeotic, is modified by Ogt. Thus, in
Drosophila
, it seems that O-linked GlcNAc has a very specific role to effect Polycomb repression.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
277 articles.
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